Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective
cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol …

The transient receptor potential (TRP) multigene superfamily encodes integral membrane
proteins that function as ion channels. Members of this family are conserved in yeast …

Transient receptor potential (TRP) channels are important mediators of sensory signals with
marked effects on cellular functions and signalling pathways. Indeed, mutations in genes …

The transient receptor potential (TRP) channel TRPV4 participates in multiple biological
processes, and numerous TRPV4 mutations underlie several distinct and devastating …

Transient receptor potential (TRP) cation channels have been among the most aggressively
pursued drug targets over the past few years. Although the initial focus of research was on …

This Review summarizes recent advances in understanding copper-transporting ATPase 1
(ATP7A), and examines the neurological phenotypes associated with dysfunction of this …

Discoveries in fruit flies have greatly contributed to our understanding of neuroscience. The
use of an unparalleled wealth of tools, many of which originated between 1910–1960, has …

Idiopathic pulmonary fibrosis (IPF) is a fatal fibrotic lung disorder with no effective medical
treatments available. The generation of myofibroblasts, which are critical for fibrogenesis …

Human monogenic pain syndromes have provided important insights into the molecular
mechanisms that underlie normal and pathological pain states. We describe an autosomal …

The transient receptor potential (TRP) superfamily of channels comprises a diverse group of
cation channels. Four TRP channel subunits coassemble to form functional homo-or …