Mitochondria play a major role in ROS production and defense during their life cycle. The
transcriptional activator PGC-1α is a key player in the homeostasis of energy metabolism …

Highlights•SIRT3, a major deacetylase in mitochondria, regulates almost every aspect of
mitochondrial health and functionality.•SIRT3 controls vital functions like energy balance …

Physical activity, including walking, has numerous health benefits in older adults, supported
by a plethora of observational and interventional studies. Walking decreases the risk or …

This review provides a comprehensive synthesis of longitudinal observational and
interventional studies on the cardiometabolic effects of coffee consumption. It explores …

Abstract Sirtuins (SIRT1-SIRT7), as a family of NAD+-dependent protein modifying enzymes,
have various catalytic functions, such as deacetylases, dealkalylases, and deribonucleases …

Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterized by a progressive
decline in lung function and poor prognosis. The deposition of the extracellular matrix (ECM) …

Doxorubicin (DOX) is a highly effective and extensively used chemotherapeutic drug but is
limited by its cardiotoxicity. In our previous study, we showed that DOX-induced …

Bazi Bushen (BZBS), a traditional Chinese medicine, has been proven effective in the
treatment of age-related disease in mouse models. However, whether its therapeutic effects …

Geroscience, an emerging discipline at the intersection of aging and disease, seeks to
understand the relationship between the aging process and pathogenesis of age-related …

Sirtuins (SIRTs) are a family of proteins with enzymatic activity. In particular, they are a family
of class III NAD+-dependent histone deacetylases and ADP-ribosyltransferases. NAD+ …