Despite the success of targeted therapies in cancer treatment, therapy-induced resistance
remains a major obstacle to a complete cure. Tumor cells evade treatments and relapse via …

The success of targeted therapies in cancer treatment has been impeded by various
mechanisms of resistance. Besides the acquisition of resistance-conferring genetic …

Histone demethylase LSD1 plays key roles during carcinogenesis, targeting LSD1 is
becoming an emerging option for the treatment of cancers. Numerous LSD1 inhibitors have …

Oxoglutarate-dependent dioxygenases (2OGDDs) are a superfamily of enzymes that play
diverse roles in many biological processes, including regulation of hypoxia-inducible factor …

Glioblastoma, the most common and aggressive malignant brain tumor, is propagated by
stem-like cancer cells refractory to existing therapies. Understanding the molecular …

Oxygen is essential for the life of most multicellular organisms. Cells possess enzymes
called molecular dioxygenases that depend on oxygen for activity. A subclass of molecular …

Post-translational modifications of histones by protein methyltransferases (PMTs) and
histone demethylases (KDMs) play an important role in the regulation of gene expression …

Members of the KDM5 histone H3 lysine 4 demethylase family are associated with
therapeutic resistance, including endocrine resistance in breast cancer, but the underlying …

Histone methylation is a key posttranslational modification of chromatin, and its
dysregulation affects a wide array of nuclear activities including the maintenance of genome …

The fast-growing body of experimental data on metalloenzymes and organometallic
compounds is fostering the exploitation of metal–ligand interactions for the design of new …