S-glutathionylation, the post-translational modification forming mixed disulfides between
protein reactive thiols and glutathione, regulates redox-based signaling events in the cell …

Glutathione is considered the major non‐protein low molecular weight modulator of redox
processes and the most important thiol reducing agent of the cell. The biosynthesis of …

The advent of advanced molecular modeling software, big data analytics, and high-speed
processing units has led to the exponential evolution of modern drug discovery and better …

Glyoxalase 2 is a mitochondrial and cytoplasmic protein belonging to the metallo-β-
lactamase family encoded by the hydroxyacylglutathione hydrolase (HAGH) gene. This …

Reactive oxygen species (ROS) are produced constantly inside the cells as a consequence
of nutrient catabolism. The balance between ROS production and elimination allows to …

The multidrug efflux system MexXY-OprM, inside the resistance-nodulation-division family, is
a major determinant of aminoglycoside resistance in Pseudomonas aeruginosa. In the fight …

Non-small cell lung cancer (NSCLC) represents a difficult condition to treat, due to
epidermal growth factor receptor (EGFR) kinase domain mutations, which lead to ligand …

Protein glutathionylation is a reversible post-translational modification that involves the
attachment of glutathione to cysteine residues. It plays a role in the regulation of several …

Permethrin is a synthetic pyrethroid extensively used as anti-woodworm agent and for
indoor and outdoor pest control. The main route of human exposure is through fruit …

Both cancer and Alzheimer's disease (AD) are emerging as metabolic diseases in which
aberrant/dysregulated glucose metabolism and bioenergetics occur, and play a key role in …