For many years, the dominant theoretical framework guiding research into the neural origins
of perceptual experience has been provided by hierarchical feedforward models, in which …

Predictive coding is possibly one of the most influential, comprehensive, and controversial
theories of neural function. While proponents praise its explanatory potential, critics object …

Perception is characterized by a reciprocal exchange of predictions and prediction error
signals between neural regions. However, the relationship between such sensory mismatch …

Using predictions based on environmental regularities is fundamental for adaptive behavior.
While it is widely accepted that predictions across different stimulus attributes (eg, time and …

Perception relies on the integration of sensory information and prior expectations. Here we
show that selective neurodegeneration of human frontal speech regions results in delayed …

Neurodegenerative diseases of the brain pose a major and increasing global health
challenge, with only limited progress made in developing effective therapies over the last …

By recording neural activity directly from the human brain, researchers gain unprecedented
insight into how neurocognitive processes unfold in real time. We first briefly discuss how …

The mismatch negativity (MMN) is a key biomarker of automatic deviance detection thought
to emerge from 2 cortical sources. First, the auditory cortex (AC) encodes spectral …

The brain draws on knowledge of statistical structure in the environment to facilitate
detection of new events. Understanding the nature of this representation is a key challenge …

How do predictions in the brain incorporate the temporal unfolding of context in our natural
environment? We here provide evidence for a neural coding scheme that sparsely updates …