The cloning of a G protein-coupled extracellular Ca2+ (Cao 2+)-sensing receptor (CaR) has
elucidated the molecular basis for many of the previously recognized effects of Cao 2+ on …

The mechanism by which epithelial and endothelial cells interact to form polarized tissue is
of fundamental importance to multicellular organisms. Dysregulation of these barriers occurs …

The Caenorhabditis elegans oocyte is a highly amenable system for forward and reverse
genetic analysis of receptor-mediated endocytosis. We describe the use of transgenic …

The low-density lipoprotein (LDL) receptor-related protein 2 (LRP2 or megalin) is
representative of the phylogenetically conserved subfamily of giant LDL receptor-related …

E-Cadherin plays critical roles in many aspects of cell adhesion, epithelial development, and
the establishment and maintenance of epithelial polarity. The fate of E-cadherin once it is …

Rab11 is a small GTP-binding protein that in cultured mammalian cells has been shown to
be concentrated in the pericentriolar endosomal recycling compartment and to play a key …

ABSTRACT Bafilomycin A1 (baf), a specific inhibitor of vacuolar proton ATPases, is
commonly employed to demonstrate the requirement of low endosomal pH for viral …

Cells lining the proximal tubule (PT) of the kidney are highly specialized for apical
endocytosis of filtered proteins and small bioactive molecules from the glomerular …

▪ Abstract Albumin is the most abundant protein in serum and contributes to the maintenance
of oncotic pressure as well as to transport of hydrophobic molecules. Although albumin is a …

Synaptotagmins (Syts) are transmembrane proteins with two Ca2+-binding C2 domains in
their cytosolic region. Syt I, the most widely studied isoform, has been proposed to function …