Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …

The past decade has witnessed an explosion in the use of super-resolution fluorescence
microscopy methods in biology and other fields. Single-molecule localization microscopy …

Inflammasome complexes are pivotal in the innate immune response. The NLR family pyrin
domain containing protein 3 (NLRP3) inflammasome is activated in response to a broad …

Summary Hydrogen peroxide (H 2 O 2) is a key redox intermediate generated within cells.
Existing probes for H 2 O 2 have not solved the problem of detection of the ultra-low …

Recently, several studies using cultures of human embryos together with single-cell RNA-
seq analyses have revealed differences between humans and mice, necessitating the study …

The mesenchymal-amoeboid transition (MAT) was proposed as a mechanism for cancer
cells to adapt their migration mode to their environment. While the molecular pathways …

INTRODUCTION The endoplasmic reticulum (ER) is a continuous, membrane-bound
organelle, spanning from the nuclear envelope to the outer cell periphery, that contacts and …

Eukaryotic cells migrate by coupling the intracellular force of the actin cytoskeleton to the
environment. While force coupling is usually mediated by transmembrane adhesion …

Super-resolution fluorescence imaging by photoactivation or photoswitching of single
fluorophores and position determination (single-molecule localization microscopy, SMLM) …

We introduce far-red, fluorogenic probes that combine minimal cytotoxicity with excellent
brightness and photostability for fluorescence imaging of actin and tubulin in living cells …