Growing evidence for intratumour heterogeneity informs us that single-site biopsies fall short
of revealing the complete genomic landscape of a tumour. With an expanding repertoire of …

Circulating tumor cells (CTCs) shed from primary and metastatic cancers are admixed with
blood components and are thus rare, making their isolation and characterization a major …

Purpose Circulating tumor cells (CTCs) may have utility as surrogate biomarkers and
“virtual” biopsies. We report the clinical significance and molecular characteristics of CTCs …

Cancer cells possess a broad spectrum of migration and invasion mechanisms. These
include both individual and collective cell-migration strategies. Cancer therapeutics that are …

Blood-borne metastasis accounts for the vast majority of cancer-related deaths and it is
fueled by the generation of circulating tumor cells (CTCs) from a primary tumor deposit …

Introduction: Epithelial circulating tumor cells (CTCs) are detectable in patients with non-
small cell lung cancer (NSCLC). However, epithelial to mesenchymal transition, a widely …

Purpose: The purpose of this study was to test the hypothesis that circulating tumor cells
(CTCs) are present in patients many years after mastectomy without evidence of disease …

The major cause of cancer-associated mortality is tumor metastasis, a disease that is far
from understood. Many studies have observed circulating tumor cells (CTCs) in patients' …

Cancer cells metastasize through the bloodstream either as single migratory circulating
tumor cells (CTCs) or as multicellular groupings (CTC clusters). Existing technologies for …

Despite major scientific, medical and technological advances over the last few decades, a
cure for cancer remains elusive. The disease initiation is complex, and including initiation …