The key proteins involved in transcriptional regulation play convergent roles in cellular
homeostasis, and their dysfunction mediates aberrant gene expressions that underline the …

Most anionic metabolites including respiratory substrates, glycolytic adenosine triphosphate
(ATP), and small cations that enter mitochondria, and mitochondrial ATP moving to the …

Background. Mitochondria are the energy factories of cells. The abnormality of mitochondrial
energy metabolism pathways is closely related to the occurrence and development of lung …

Non-coding RNA has aroused great research interest recently, they play a wide range of
biological functions, such as regulating cell cycle, cell proliferation, and intracellular …

Colorectal cancer (CRC) represents a significant global health burden, with high incidence
and mortality rates worldwide. Recent progress in research highlights the distinct clinical …

Pyruvate carboxylase (PC) is a tetrameric enzyme that contains two active sites per subunit
that catalyze two consecutive reactions. A mobile domain with an attached prosthetic biotin …

Erianin, a bioactive compound extracted from Dendrobium, a traditional Chinese medicine,
exhibits remarkable anti-cancer properties through diverse molecular mechanisms and has …

Cancer cell proliferation in some organs often depends on conversion of pyruvate to
oxaloacetate via pyruvate carboxylase (PC) for replenishing the tricarboxylic acid cycle to …

The active removal of DNA methylation marks is governed by the ten-eleven translocation
(TET) family of enzymes (TET1–3), which iteratively oxidize 5-methycytosine (5mC) into 5 …

Diabetes mellitus is a metabolic disorder characterized by hyperglycemia due to impaired
insulin secretion, insulin resistance, or both. Oxidative stress and chronic low-grade …