Extrachromosomal DNA (ecDNA): Unveiling its role in cancer progression and implications for early detection

S Wu, T Tao, L Zhang, X Zhu, X Zhou - Heliyon, 2023 - cell.com
Extrachromosomal DNA (ecDNA) is a special class of circular DNA in eukaryotes, which is
independent of conventional chromosomes. These circular molecules play important roles in …

Unveiling the mysteries of extrachromosomal circular DNA: from generation to clinical relevance in human cancers and health

Z Wang, J Yu, W Zhu, X Hong, Z Xu, S Mao, L Huang… - Molecular Cancer, 2024 - Springer
Extrachromosomal circular DNAs (eccDNAs) are a type of circular DNAs originating from but
independent of chromosomal DNAs. Nowadays, with the rapid development of sequencing …

Predicting gestational diabetes mellitus risk at 11–13 weeks' gestation: the role of extrachromosomal circular DNA

J Wang, P Huang, F Hou, D Hao, W Li, H Jin - Cardiovascular Diabetology, 2024 - Springer
Background Gestational diabetes mellitus (GDM) significantly impacts maternal and infant
health both immediately and over the long term, yet effective early diagnostic biomarkers are …

Characterization, biogenesis model, and current bioinformatics of human extrachromosomal circular DNA

L Zhou, W Tang, B Ye, L Zou - Frontiers in Genetics, 2024 - frontiersin.org
Human extrachromosomal circular DNA, or eccDNA, has been the topic of extensive
investigation in the last decade due to its prominent regulatory role in the development of …

[HTML][HTML] Beyond the Chromosome: Recent Developments in Decoding the Significance of Extrachromosomal Circular DNA (eccDNA) in Human Malignancies

P Tsiakanikas, K Athanasopoulou, IA Darioti… - Life, 2024 - mdpi.com
Extrachromosomal circular DNA (eccDNA) is a form of a circular double-stranded DNA that
exists independently of conventional chromosomes. eccDNA exhibits a broad and random …

Decoding the genomic enigma: Approaches to studying extrachromosomal circular DNA

XQ Yuan, N Zhou, SJ Song, YX Xie, SQ Chen, TF Yang… - Heliyon, 2024 - cell.com
Extrachromosomal circular DNA (eccDNA), a pervasive yet enigmatic component of the
eukaryotic genome, exists autonomously from its chromosomal counterparts. Ubiquitous in …

Advances and challenges in the use of liquid biopsy in gynaecological oncology

Y Zhang, L Tian - Heliyon, 2024 - cell.com
Ovarian cancer, endometrial cancer, and cervical cancer are the three primary
gynaecological cancers that pose a significant threat to women's health on a global scale …