Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

H Luo, CT Vong, H Chen, Y Gao, P Lyu, L Qiu, M Zhao… - Chinese medicine, 2019 - Springer
Numerous natural products originated from Chinese herbal medicine exhibit anti-cancer
activities, including anti-proliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects …

From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy

T Efferth - Seminars in cancer biology, 2017 - Elsevier
Artemisia annua L. is used throughout Asia and Africa as tea and press juice to treat malaria
and related symptomes (fever, chills). Its active ingredient, artemisinin (ARS), has been …

Anticancer activity of artemisinin and its derivatives

S Slezáková, J Ruda-Kucerova - Anticancer research, 2017 - ar.iiarjournals.org
Artemisinin is an extract from the plant Artemisia annua. With its semi-synthetic derivatives,
they form a group of well-known and efficacious antimalarial drugs. Recent studies have …

Artesunate inhibits growth of sunitinib-resistant renal cell carcinoma cells through cell cycle arrest and induction of ferroptosis

SD Markowitsch, P Schupp, J Lauckner… - Cancers, 2020 - mdpi.com
Simple Summary Renal cell carcinoma (RCC) is the most common kidney malignancy. Due
to development of therapy resistance, efficacy of conventional drugs such as sunitinib is …

Sesquiterpenes and their derivatives-natural anticancer compounds: An update

T Abu-Izneid, A Rauf, MA Shariati, AA Khalil… - Pharmacological …, 2020 - Elsevier
Sesquiterpenes belong to the largest group of plant secondary metabolites, which consist of
three isoprene building units. These compounds are widely distributed in various …

[HTML][HTML] Medicinal and mechanistic overview of artemisinin in the treatment of human diseases

AM Posadino, R Giordo, G Pintus… - Biomedicine & …, 2023 - Elsevier
Artemisinin (ART) is a bioactive compound isolated from the plant Artemisia annua and has
been traditionally used to treat conditions such as malaria, cancer, viral infections, bacterial …

The transcription factors TLR1 and TLR2 negatively regulate trichome density and artemisinin levels in Artemisia annua

Z Lv, JX Li, S Qiu, F Qi, H Su, Q Bu… - Journal of Integrative …, 2022 - Wiley Online Library
The important antimalarial drug artemisinin is biosynthesized and stored in Artemisia annua
glandular trichomes and the artemisinin content correlates with trichome density; however …

Repurposing artemisinin and its derivatives as anticancer drugs: a chance or challenge?

Z Ma, CYN Woon, CG Liu, JT Cheng, M You… - Frontiers in …, 2021 - frontiersin.org
Cancer has become a global health problem, accounting for one out of six deaths. Despite
the recent advances in cancer therapy, there is still an ever-growing need for readily …

Recent pharmacological advances in the repurposing of artemisinin drugs

Y Meng, N Ma, H Lyu, YK Wong… - Medicinal research …, 2021 - Wiley Online Library
Artemisinins are a family of sesquiterpene lactones originally derived from the sweet
wormwood (Artemisia annua). Beyond their well‐characterized role as frontline antimalarial …

Artemisinins in combating viral infections like SARS-CoV-2, inflammation and cancers and options to meet increased global demand

K Farmanpour-Kalalagh… - Frontiers in Plant …, 2022 - frontiersin.org
Artemisinin is a natural bioactive sesquiterpene lactone containing an unusual
endoperoxide 1, 2, 4-trioxane ring. It is derived from the herbal medicinal plant Artemisia …