Induced pluripotent stem cells (iPSCs) can self-renew indefinitely in culture and differentiate
into all specialized cell types including gametes. iPSCs do not exist naturally and are …

CRISPR/Cas9 system exploits the concerted action of Cas9 nuclease and programmable
single guide RNA (sgRNA), and has been widely used for genome editing. The Cas9 …

Congenital heart disease (CHD) is a multifaceted cardiovascular anomaly that occurs when
there are structural abnormalities in the heart before birth. Although various risk factors are …

The persistence of cardiovascular diseases as leading global causes of death has spurred
attempts to develop microphysiological systems integrating engineered cardiac tissue …

Background: Long-lasting local anesthetic use for perioperative pain control is limited by
possible cardiotoxicity (eg, arrhythmias and contractile depression), potentially leading to …

In vitro reconstruction of highly mature engineered heart tissues (EHTs) is attempted for the
selection of cardiotoxic drugs suitable for individual patients before administration …

Carbon nanotubes (CNTs) are known for their excellent conductive properties. Here, we
present two novel methods,“sandwich”(sCNT) and dual deposition (DD CNT), for …

The CRISPR/Cas9 system is a powerful tool for genome editing, utilizing the Cas9 nuclease
and programmable single guide RNA (sgRNA). However, the Cas9 nuclease activity can be …

Utilizing recent advances in human induced pluripotent stem cell (hiPSC) technology,
nonlinear analysis and machine learning we can create novel tools to evaluate drug …

Tissue engineering (TE) combines cells, scaffolds, and growth factors to assemble functional
tissues for repair or replacement of tissues and organs. Cardiac TE is focused on developing …