The past decade has seen the emergence of endoplasmic reticulum (ER) chaperones as
key determinants of contact formation between mitochondria and the ER on the …

Abstract The sigma-1 receptor (Sig-1R) is encoded by the SIGMAR1 gene and is a
nonopioid transmembrane receptor located in the mitochondrial-associated endoplasmic …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting upper and
lower motor neurons. As a consequence, ALS patients display a locomotor disorder related …

Dry age‐related macular degeneration (dAMD) is a chronic degenerative ophthalmopathy
that leads to serious burden of visual impairment. Antioxidation in retinal pigment epithelium …

Sigma receptors are non-opiate/non-phencyclidine receptors that bind progesterone and/or
heme and also several unrelated xenobiotics/chemicals. They reside in the plasma …

In a subgroup of patients with amyotrophic lateral sclerosis (ALS)/Frontotemporal dementia
(FTD), the (G4C2)-RNA repeat expansion from C9orf72 chromosome binds to the Ran …

Sigma‐1 receptor (Sig1R), a chaperone in the endoplasmic reticulum (ER) membrane, has
been implicated in cardiac hypertrophy; however, its role in cardiac fibroblast activation has …

Parkinson's disease is a neurodegenerative disease affecting mainly the elderly population.
It is characterized by the loss of dopaminergic neurons of the substantia nigra pars …

The retinal degeneration 10 (rd10) mouse model is widely used to study retinitis pigmentosa
(RP) pathomechanisms. It offers a rather unique opportunity to study trans-neuronal …

Spinal cord injury (SCI) causes long-term and severe disability, influencing the quality of life
and triggering serious socioeconomic consequences. Lack of effective pharmacotherapies …