Reprogrammed metabolism is a hallmark of cancer. However, the metabolic dependency of
cancer, from tumour initiation through disease progression and therapy resistance, requires …

Increased reactive oxygen species (ROS) production has been detected in various cancers
and has been shown to have several roles, for example, they can activate pro-tumourigenic …

Elevated intracellular reactive oxygen species (ROS) and antioxidant defense systems have
been recognized as one of the hallmarks of cancer cells. Compared with normal cells …

Acute myeloid leukaemia (AML) is an aggressive haematological malignancy with a poor
overall survival. Reactive oxygen species (ROS) have been shown to be elevated in a wide …

Transforming growth factor beta (TGF-β) plays key roles in regulating cellular proliferation
and maintaining tissue homeostasis. TGF-β exerts tumor-suppressive effects in the early …

The NADPH oxidase (NOX) family of enzymes produces ROS as their sole function and is
becoming recognized as key modulators of signal transduction pathways with a …

Abstract Significance: Reduction/oxidation (redox) balance could be defined as an even
distribution of reduction and oxidation complementary processes and their reaction end …

The main hematopoietic stem cell (HSC) functions, self-renewal and differentiation, are
finely regulated by both intrinsic mechanisms such as transcriptional and epigenetic …

Reactive oxygen species (ROS) are important signaling molecules that act through the
oxidation of nucleic acids, proteins, and lipids. Several hallmarks of cancer, including …

Mutations in the type III receptor tyrosine kinase FLT3 are frequent in patients with acute
myeloid leukemia (AML) and are associated with a poor prognosis. AML is characterized by …