Capillary forces generated by biomolecular condensates

B Gouveia, Y Kim, JW Shaevitz, S Petry, HA Stone… - Nature, 2022 - nature.com
Liquid–liquid phase separation and related phase transitions have emerged as generic
mechanisms in living cells for the formation of membraneless compartments or biomolecular …

Mechanisms of microtubule organization in differentiated animal cells

A Akhmanova, LC Kapitein - Nature Reviews Molecular Cell Biology, 2022 - nature.com
Microtubules are polarized cytoskeletal filaments that serve as tracks for intracellular
transport and form a scaffold that positions organelles and other cellular components and …

Microtubules and microtubule-associated proteins

HV Goodson, EM Jonasson - Cold Spring Harbor …, 2018 - cshperspectives.cshlp.org
Microtubules act as “railways” for motor-driven intracellular transport, interact with accessory
proteins to assemble into larger structures such as the mitotic spindle, and provide an …

Microtubule dynamics: an interplay of biochemistry and mechanics

GJ Brouhard, LM Rice - Nature reviews Molecular cell biology, 2018 - nature.com
Microtubules are dynamic polymers of αβ-tubulin that are essential for intracellular
organization, organelle trafficking and chromosome segregation. Microtubule growth and …

Control of microtubule organization and dynamics: two ends in the limelight

A Akhmanova, MO Steinmetz - Nature reviews Molecular cell biology, 2015 - nature.com
Microtubules have fundamental roles in many essential biological processes, including cell
division and intracellular transport. They assemble and disassemble from their two ends …

Mitotic spindle assembly in animal cells: a fine balancing act

SL Prosser, L Pelletier - Nature Reviews Molecular Cell Biology, 2017 - nature.com
The mitotic spindle has a crucial role in ensuring the accurate segregation of chromosomes
into the two daughter cells during cell division, which is paramount for maintaining genome …

Microtubule-organizing centers: from the centrosome to non-centrosomal sites

AD Sanchez, JL Feldman - Current opinion in cell biology, 2017 - Elsevier
The process of cellular differentiation requires the distinct spatial organization of the
microtubule cytoskeleton, the arrangement of which is specific to cell type. Microtubule …

Phase separation of TPX2 enhances and spatially coordinates microtubule nucleation

MR King, S Petry - Nature communications, 2020 - nature.com
Phase separation of substrates and effectors is proposed to enhance biological reaction
rates and efficiency. Targeting protein for Xklp2 (TPX2) is an effector of branching …

Microtubule nucleation: beyond the template

J Roostalu, T Surrey - Nature Reviews Molecular Cell Biology, 2017 - nature.com
Microtubules are cytoskeletal filaments central to a wide range of essential cellular functions
in eukaryotic cells. Consequently, cells need to exert tight control over when, where and how …

Mechanisms underlying spindle assembly and robustness

VA Valdez, L Neahring, S Petry… - Nature Reviews Molecular …, 2023 - nature.com
The microtubule-based spindle orchestrates chromosome segregation during cell division.
Following more than a century of study, many components and pathways contributing to …