Malignant brain tumors strike deep into the psyche of those receiving and those delivering
the diagnosis. Malignant gliomas, the most common subtype of primary brain tumors, are …

Postmitotic neurons are produced from a pool of cycling progenitors in an orderly fashion
during development. Studies of cell-fate determination in the vertebrate retina have …

In the developing neural retina (NR), multipotent stem cells within the ciliary margin (CM)
contribute to de novo retinal tissue growth. We recently reported the ability of human …

Adult zebrafish generate new neurons in the brain and retina throughout life. Growth-related
neurogenesis allows a vigorous regenerative response to damage, and fish can regenerate …

Adult CNS neurons are typically described as permanently postmitotic but there is probably
nothing permanent about the neuronal cell cycle arrest. Rather, it appears that these highly …

Müller glial cells are the major support cell for neurons in the vertebrate retina. Following
neuronal damage, Müller cells undergo reactive gliosis, which is characterized by …

We are interested in the mechanisms of glial cell development in the vertebrate central
nervous system. We have identified genes that can direct the formation of glia in the retina …

In the olfactory epithelium (OE), generation of new neurons by neuronal progenitors is
inhibited by a signal from neurons themselves. Here we provide evidence that this feedback …

Sustained blood cell production requires preservation of a quiescent, multipotential stem cell
pool that intermittently gives rise to progenitors with robust proliferative potential. The ability …

Mammalian organogenesis requires the expansion of pluripotent precursor cells before the
subsequent determination of specific cell types, but the tissue-specific molecular …