Publisher Summary This chapter focuses on principles for multivalent ligand design. Multivalent interactions control a wide variety of cellular processes including cell surface …
The plasma membrane of cells contains a diverse array of lipids that provide important structural and biological features. Glycolipids are typically a minor component of the cell …
TK Lindhorst, S Kötter, U Krallmann-Wenzel… - Journal of the Chemical …, 2001 - pubs.rsc.org
Structural modifications of trivalent cluster mannosides are presented to further elucidate the ligand preferences of the type-1 fimbrial lectin of Escherichia coli. Two types of variations are …
BT Houseman, M Mrksich - Host-Guest Chemistry: Mimetic Approaches to …, 2002 - Springer
This chapter describes several classes of model systems that have been used for studies of polyvalent binding interactions between carbohydrates and proteins. This review is divided …
Carbohydrates are the most abundant group of natural products and the role of sugars as energy and biosynthetic resources (glycolysis, pentose phosphate cycle, etc.),'energy …
B Dhakal, A Mandhapati, P Eradi, S Park… - Journal of the …, 2024 - ACS Publications
The high affinity interaction between P-selectin glycoprotein ligand-1 (PSGL-1) and P- selectin is mediated by a multimotif glycosulfopeptide (GSP) recognition domain consisting …
A Geyer, C Gege, RR Schmidt - … Chemie International Edition, 2000 - Wiley Online Library
During adhesion events in eukaryotic cells polyvalent carbohydrate–carbohydrate recognition between LeX oligosaccharides plays a role. Clustering was mimicked by a …
SL Flitsch - Current Opinion in Chemical Biology, 2000 - Elsevier
The development of efficient, fast, flexible and general synthetic routes to glycopolymers is an ongoing challenge and much progress has been made in recent years. Chemical …
Solid-supported membrane multilayers doped with membrane-anchored oligosaccharides bearing the LewisX motif (Le X lipid) were utilized as a model system of membrane …