A large number of clinical trials have shown stem cell therapy to be a promising therapeutic
approach for the treatment of cardiovascular diseases. Since the first transplantation into …

Heart Diseases are serious and global public health concern. In spite of remarkable
therapeutic developments, the prediction of patients with Heart Failure (HF) is weak, and …

Genetic deficiency of dystrophin leads to disability and premature death in Duchenne
muscular dystrophy (DMD), affecting the heart as well as skeletal muscle. Here, we report …

The cell origin-specific payloads within extracellular vesicles (EVs) mediate therapeutic
bioactivity for a wide variety of stem cell types. In this study, we profiled the microRNA …

The development of cells for regenerative therapy has encountered many pitfalls on its path
to clinical translation. In cardiology, clinical studies of heart-targeted cell therapies began …

Exosomes are nano-sized vesicles released by numerous cell types that appear to have
diverse beneficial effects on the injured heart. Studies using exosomes from stem cells or …

Objectives: This study sought to compare the regenerative potency of cells derived from
healthy and diseased human hearts. Background: Results from pre-clinical studies and the …

Background The regenerative potential of cardiosphere‐derived cells (CDC s) for ischemic
heart disease has been demonstrated in mice, rats, pigs, and a recently completed clinical …

Current approaches in myocardial infarction treatment are limited by low cellular oxidative
stress resistance, reducing the long-term survival of therapeutic cells. Here we develop a …

Over the past two decades, several populations of cardiac stem cells have been described
in the adult mammalian heart. For the most part, however, their lineage origins and in vivo …