Hybrid molecules based on caffeic acid as potential therapeutics: A focused review
X Zhao, Z Liu, H Liu, J Guo, S Long - European Journal of Medicinal …, 2022 - Elsevier
Caffeic acid-based compounds possess a high degree of structural diversity and show a
variety of pharmacological properties, providing a useful framework for the discovery of new …
variety of pharmacological properties, providing a useful framework for the discovery of new …
[HTML][HTML] Cyclooxygenase-2 (COX-2) as a target of anticancer agents: A review of novel synthesized scaffolds having anticancer and COX-2 inhibitory potentialities
Cancer is a serious threat to human beings and is the second-largest cause of death all over
the globe. Chemotherapy is one of the most common treatments for cancer; however, drug …
the globe. Chemotherapy is one of the most common treatments for cancer; however, drug …
New Insights Into the Anticancer Effects of p-Coumaric Acid: Focus on Colorectal Cancer
Colorectal cancer is considered the second most deadly cancer in the world. Studies have
indicated that diet can prevent the risk of developing colorectal cancer. Recently, there has …
indicated that diet can prevent the risk of developing colorectal cancer. Recently, there has …
[HTML][HTML] Optimization of pyrazolo [1, 5-a] pyrimidine based compounds with pyridine scaffold: Synthesis, biological evaluation and molecular modeling study
MA Abdelgawad, NAA Elkanzi, A Musa… - Arabian Journal of …, 2022 - Elsevier
Background Pyrazolopyrimidine heterocycle and its isosteres represent the main scaffold for
many pharmacologically active drugs including anti-inflammatory agents. The COX-2 …
many pharmacologically active drugs including anti-inflammatory agents. The COX-2 …
Green Design, Synthesis, and Molecular Docking Study of Novel Quinoxaline Derivatives with Insecticidal Potential against Aphis craccivora
An efficient and environmentally friendly method was established for designing novel 3-
amino-1, 4-dihydroquinoxaline-2-carbonitrile (1) via the reaction of bromomalononitrile and …
amino-1, 4-dihydroquinoxaline-2-carbonitrile (1) via the reaction of bromomalononitrile and …
Small-molecule drugs of colorectal cancer: Current status and future directions
Y Yang, P Liu, M Zhou, L Yin, M Wang, T Liu… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the world's
fourth most deadly cancer. CRC, as a genetic susceptible disease, faces significant …
fourth most deadly cancer. CRC, as a genetic susceptible disease, faces significant …
Epidermal growth factor receptor dual-target inhibitors as a novel therapy for cancer: A review
C Wang, Y Zhang, T Zhang, J Xu, S Yan, B Liang… - International Journal of …, 2023 - Elsevier
Overexpression of the epidermal growth factor receptor (EGFR) has been linked to several
human cancers, including esophageal cancer, pancreatic cancer, anal cancer, breast …
human cancers, including esophageal cancer, pancreatic cancer, anal cancer, breast …
[HTML][HTML] EGFR and COX-2 dual inhibitor: the design, synthesis, and biological evaluation of novel chalcones
For most researchers, discovering new anticancer drugs to avoid the adverse effects of
current ones, to improve therapeutic benefits and to reduce resistance is essential. Because …
current ones, to improve therapeutic benefits and to reduce resistance is essential. Because …
Explainable artificial intelligence-assisted virtual screening and bioinformatics approaches for effective bioactivity prediction of phenolic cyclooxygenase-2 (COX-2) …
Abstract Cyclooxygenase-2 (COX-2) inhibitors are nonsteroidal anti-inflammatory drugs that
treat inflammation, pain and fever. This study determined the interaction mechanisms of …
treat inflammation, pain and fever. This study determined the interaction mechanisms of …
[HTML][HTML] Modulating effects of zingiberaceae phenolic compounds on neurotrophic factors and their potential as neuroprotectants in brain disorders and age …
The Zingiberaceae family possess various phenolic compounds that have significant
systemic bioactivities in the brain, including in age-related neurodegenerative diseases …
systemic bioactivities in the brain, including in age-related neurodegenerative diseases …