Neuroblastomas are tumours of sympathetic origin, with a heterogeneous clinical course
ranging from localized or spontaneously regressing to widely metastatic disease …

Dysregulated expression of the transcription factor MYCN is frequently detected in nervous
system tumors such as childhood neuroblastoma. Here, gene amplification of MYCN is a …

Neuroblastoma is a pediatric tumor of the sympathetic nervous system. Its clinical course
ranges from spontaneous tumor regression to fatal progression. To investigate the molecular …

We explored the utility of targeting anaplastic lymphoma kinase (ALK), a cell surface
receptor overexpressed on pediatric solid tumors, using chimeric antigen receptor (CAR) …

Neuroblastoma is a neural crest derived malignancy of the peripheral nervous system and is
the most common and deadliest tumor of infancy. It is characterized by clinical heterogeneity …

Neuroblastoma, the most common extracranial solid tumor of childhood, is thought to
originate from undifferentiated neural crest cells. Amplification of the MYC family member …

Neuroblastoma is a solid tumour that arises from the developing sympathetic nervous
system. Over the past decade, our understanding of this disease has advanced …

ABSTRACT A vast array of oncogenic variants has been identified for anaplastic lymphoma
kinase (ALK). Therefore, there is a need to better understand the role of ALK in cancer …

The burgeoning field of anaplastic lymphoma kinase (ALK) in cancer encompasses many
cancer types, from very rare cancers to the more prevalent non-small-cell lung cancer …

Neuroblastoma (NB), the most common extracranial tumor of childhood, is a cancer of
primordial neural crest cells that give rise to sympathetic neural ganglia and adrenal …