Driven by autonomous molecular clocks that are synchronized by a master pacemaker in the
suprachiasmatic nucleus, cardiac physiology fluctuates in diurnal rhythms that can be partly …

Background Nicotinamide adenine dinucleotide (NAD+) metabolism is involved in the entire
physiopathological process and is critical to human health. Long-term imbalance in NAD+ …

REV-ERB nuclear receptors are potent transcriptional repressors that play an important role
in the core mammalian molecular clock and metabolism. Deletion of both REV-ERBα and its …

Background: The nuclear receptor Rev-erbα/β, a key component of the circadian clock,
emerges as a drug target for heart diseases, but the function of cardiac Rev-erb has not …

Circadian gene transcription is fundamental to metabolic physiology. Here we report that the
nuclear receptor REV-ERBα, a repressive component of the molecular clock, forms circadian …

Molecular clocks in the periphery coordinate tissue-specific daily biorhythms by integrating
input from the hypothalamic master clock and intracellular metabolic signals. One such key …

Recent research has unveiled an expansive role of NAD+ in cellular energy generation,
redox reactions, and as a substrate or cosubstrate in signaling pathways that regulate health …

Circadian mechanisms have been associated with the pathogenesis of a variety of
cardiovascular diseases, including myocardial ischemia-reperfusion injury (IR). Myocardial …

Time plays a crucial role in the regulation of physiological processes. Without a temporal
control system, animals would be unprepared for cyclic environmental changes, negatively …

Circadian disruption increases cardiovascular disease (CVD) risk, through poorly
understood mechanisms. Given that small RNA species are critical modulators of cardiac …