Since the discovery of X-ray diffraction and its potential to elucidate crystal symmetry,
powder X-ray diffraction has found diverse applications in the field of pharmaceutical …

For poorly water soluble drugs, the amorphous state provides an avenue to enhance oral
bioavailability. The preparation method, in addition to sample history, can dictate the nature …

Tablets of amorphous indomethacin were compressed at 10, 25, 50, or 100 MPa using
either an unlubricated or a lubricated die and stored individually at 35° C in sealed Mylar …

Phase transformation of an active pharmaceutical ingredient in the solid state can influence
the physicochemical properties and consequently drug product performance. The neat …

While screening the counter-ions for salt selection for an active pharmaceutical substance,
there is often an uncertainty about disproportionation of the salt and hence physical stability …

Tablets containing a theophylline–glutaric acid (TG) cocrystal dissociated rapidly forming
crystalline theophylline (20–30%), following storage at 40° C/75% RH for 2 weeks. Control …

Our objective is to mechanistically understand the implications of processing-induced lattice
disorder on the stability of pharmaceutical cocrystals. Caffeine–oxalic acid (CAFOXA) and …

Our goals were to evaluate the effects of (i) hydrostatic pressure alone and (ii) its combined
effect with shear stress during compaction, on the polymorphic transformation (form C→ A) …

Tablets which were binary mixtures of pioglitazone hydrochloride (PioHCl) with magnesium
stearate (MgSt), croscarmellose sodium (CCS), microcrystalline cellulose, or lactose …

Water is ubiquitous during pharmaceutical product development and may interact with the
drug substance, formulation additives and the drug product in either solvent or vapor form …