Dengue is a mosquito-borne viral disease (arboviral) caused by the Dengue virus. It is one
of the prominent public health problems in tropical and subtropical regions with no effective …

Viruses are obligate intracellular parasites; they heavily depend on the host cell machinery
to effectively replicate and produce new progeny virus particles. Following viral infection …

Sphingolipids are essential components of all eukaryotic membranes. The bioactive
sphingolipid molecule, Sphingosine 1-Phosphate (S1P), regulates various important …

Apoptosis is a form of programmed cell death, which maintains cellular homeostasis by
eliminating pathogen-infected cells. It contains three signaling pathways: death receptor …

The innate immune system is the host's first line of defense against the invasion of
pathogens including flavivirus. The programmed cell death controlled by genes plays an …

Background Fibrinogen has an established, essential role in both coagulation and
inflammatory pathways, and these processes are deeply intertwined in the development of …

Two decades ago, sphingosine 1-phosphate (S1P) was discovered as a novel bioactive
molecule that regulates a variety of cellular functions. The plethora of S1P-mediated effects …

The sphingosine 1-phosphate (S1P) metabolic pathway is a dynamic regulator of multiple
cellular and disease processes. Identification of the immune regulatory role of the …

Efficient virus replication in Aedes vector mosquitoes is essential for the transmission of
arboviral diseases such as dengue virus (DENV) in human populations. Like in vertebrates …

Dengue virus (DENV) infection is a disease that is endemic to many parts of the world, and
its increasing prevalence ranks it among the diseases considered to be a significant threat to …