Objective To assess the associations between statins and adverse events in primary
prevention of cardiovascular disease and to examine how the associations vary by type and …

Simple Summary The genomics-based concept of precision medicine began to emerge
following the completion of the Human Genome Project. In contrast to evidence-based …

The gut microbiome has emerged as an important factor affecting human health and
disease. The recent development of–omics approaches, including phylogenetic marker …

Compared with drugs from the blockbuster era, recently authorized drugs and those
expected in the future present a heterogenous mix of chemicals, biologicals, and cell and …

The brain regulates information flow by balancing the segregation and integration of
incoming stimuli to facilitate flexible cognition and behaviour. The topological features of …

In the era of precision medicine, digital technologies and artificial intelligence, drug
discovery and development face unprecedented opportunities for product and business …

Objective Complex phenotypes captured on histological slides represent the biological
processes at play in individual cancers, but the link to underlying molecular classification …

Patients with mental disorders show many biological abnormalities which distinguish them
from normal volunteers; however, few of these have led to tests with clinical utility. Several …

Model-informed precision dosing (MIPD) has become synonymous with modern approaches
for individualizing drug therapy, in which the characteristics of each patient are considered …

The synovium is the major target tissue of inflammatory arthritides such as rheumatoid
arthritis. The study of synovial tissue has advanced considerably throughout the past few …