With the insufficient satisfaction rates and high cost of operative treatment for osteoarthritis
(OA), alternatives have been sought. Furthermore, the inability of current medications to …

Osteoarthritis (OA) has been proven as the second primary cause of pain and disability in
the elderly population, impact patients both physically and mentally, as well as imposing a …

The repair of growth plate injuries is a highly complex process that involves precise
spatiotemporal regulation of multiple cell types. While significant progress has been made in …

Although MSCs grant pronounced potential for cell therapies, several factors, such as their
heterogeneity restrict their use. To overcome these limitations, iMSCs (MSCs derived from …

Cancerous cells are characterised by their ability to invade, metastasise, and induce
angiogenesis. Tumour cells use various molecules that can be targeted to reverse these …

Osteoarthritis (OA) causes disability and significant economic and social burden. Cartilage
injury is one of the main pathological features of OA, and is often manifested by excessive …

Despite significant advances in biomedical research, osteochondral defects resulting from
injury, an autoimmune condition, cancer, or other pathological conditions still represent a …

Bone marrow stem cell (BMSC)-regenerated cartilage (BRC) shows promising prospects for
clinically repairing cartilage defects. However, when subcutaneously implanted into …

Background: In the environment of cartilage injury, the activation of vascular endothelial cell
(VEC), marked with excessive CD62E and reactive oxygen species (ROS), can affect the …

Increasing evidence indicates that peripheral blood vessels play a pivotal role in regulating
tumor growth with the presence of new blood vessels facilitating tumor growth and …