The routine and often unavoidable exposure to solar ultraviolet (UV) radiation makes it one
of the most significant environmental DNA-damaging agents to which humans are exposed …

Oxidative DNA damage constitutes a major threat to genetic integrity, and has thus been
implicated in the pathogenesis of a wide variety of diseases, including cancer and …

Highlights•Humans encode 16 bone-fide DNA polymerases.•Replicative DNA polymerases
are emerging as highly flexible and dynamic in their interactions.•Mutations in replicative …

DNA polymerases were named for their function of catalysing DNA replication, a process
that is necessary for growth and propagation of life. DNA involving Watson–Crick base …

DNA double-strand breaks (DSBs) threaten genomic stability, since their persistence can
lead to loss of critical genetic information, chromosomal translocations or rearrangements …

Replicative errors contribute to the genetic diversity needed for evolution but in high
frequency can lead to genomic instability. Here, we show that DNA dynamics determine the …

Low‐dose 5‐aminolevulinic acid photodynamic therapy (ALA‐PDT) has been used to cope
with skin photoaging, and is thought to involve DNA damage repair responses. However, it …

Most of the neurodegenerative diseases and aging are associated with reactive oxygen
species (ROS) or other intracellular damaging agents that challenge the genome integrity of …

7, 8-Dihydro-8-oxoguanine (oxoG) is the most abundant oxidative DNA lesion with dual
coding properties. It forms both Watson–Crick (anti) oxoG:(anti) C and Hoogsteen (syn) …

The oxidative base damage, 8-oxo-7, 8-dihydroguanine (8-oxoG) is a highly mutagenic
lesion because replicative DNA polymerases insert adenine (A) opposite 8-oxoG. In …