Harnessing the potential of hydrogels for advanced therapeutic applications: Current achievements and future directions

P Lu, D Ruan, M Huang, M Tian, K Zhu… - Signal transduction and …, 2024 - nature.com
The applications of hydrogels have expanded significantly due to their versatile, highly
tunable properties and breakthroughs in biomaterial technologies. In this review, we cover …

Bioengineered nanogels for cancer immunotherapy

X Ma, SJ Li, Y Liu, T Zhang, P Xue, Y Kang… - Chemical Society …, 2022 - pubs.rsc.org
Recent years have witnessed increasingly rapid advances in nanocarrier-based
biomedicine aimed at improving treatment paradigms for cancer. Nanogels serve as …

[HTML][HTML] Strategies in the delivery of Cas9 ribonucleoprotein for CRISPR/Cas9 genome editing

S Zhang, J Shen, D Li, Y Cheng - Theranostics, 2021 - ncbi.nlm.nih.gov
CRISPR/Cas9 genome editing has gained rapidly increasing attentions in recent years,
however, the translation of this biotechnology into therapy has been hindered by efficient …

Nanogels: Synthesis, properties, and recent biomedical applications

QY Duan, YX Zhu, HR Jia, SH Wang, FG Wu - Progress in Materials …, 2023 - Elsevier
Nanogels, also termed hydrogel nanoparticles, have the properties and functions of both
nanomaterials and hydrogels. Till date, a considerable number of nanogels have been …

Exosome-mediated delivery of gene vectors for gene therapy

L Duan, L Xu, X Xu, Z Qin, X Zhou, Y Xiao, Y Liang… - Nanoscale, 2021 - pubs.rsc.org
Gene vectors are nucleic acids that carry genetic materials or gene editing devices into cells
to exert the sustained production of therapeutic proteins or to correct erroneous genes of the …

DNA hydrogel-based gene editing and drug delivery systems

F Mo, K Jiang, D Zhao, Y Wang, J Song… - Advanced Drug Delivery …, 2021 - Elsevier
Deoxyribonucleic acid (DNA) is a promising synthesizer for precisely constructing almost
arbitrary geometry in two and three dimensions. Among various DNA-based soft materials …

New developments in medical applications of hybrid hydrogels containing natural polymers

C Vasile, D Pamfil, E Stoleru, M Baican - Molecules, 2020 - mdpi.com
New trends in biomedical applications of the hybrid polymeric hydrogels, obtained by
combining natural polymers with synthetic ones, have been reviewed …

[HTML][HTML] Nucleic acid nanoassembly-enhanced RNA therapeutics and diagnosis

M Zhao, R Wang, K Yang, Y Jiang, Y Peng, Y Li… - … Pharmaceutica Sinica B, 2023 - Elsevier
RNAs are involved in the crucial processes of disease progression and have emerged as
powerful therapeutic targets and diagnostic biomarkers. However, efficient delivery of …

Non-viral delivery of the CRISPR/Cas system: DNA versus RNA versus RNP

Y Lin, E Wagner, U Lächelt - Biomaterials Science, 2022 - pubs.rsc.org
Since its discovery, the CRISPR/Cas technology has rapidly become an essential tool in
modern biomedical research. The opportunities to specifically modify and correct genomic …

Biomaterial-assisted targeted and controlled delivery of CRISPR/Cas9 for precise gene editing

Z Iqbal, K Rehman, J Xia, M Shabbir, M Zaman… - Biomaterials …, 2023 - pubs.rsc.org
RISPR-Cas9 has exhibited enormous potential in gene therapy. It can perform genome
editing with single-nucleotide precision in various types of cell and tissue, providing a …