Applied machine learning in Alzheimer's disease research: omics, imaging, and clinical data
Alzheimer's disease (AD) remains a devastating neurodegenerative disease with few
preventive or curative treatments available. Modern technology developments of high …
preventive or curative treatments available. Modern technology developments of high …
Harnessing endophenotypes and network medicine for Alzheimer's drug repurposing
Following two decades of more than 400 clinical trials centered on the “one drug, one target,
one disease” paradigm, there is still no effective disease‐modifying therapy for Alzheimer's …
one disease” paradigm, there is still no effective disease‐modifying therapy for Alzheimer's …
[HTML][HTML] Repurposed agents in the Alzheimer's disease drug development pipeline
J Bauzon, G Lee, J Cummings - Alzheimer's research & therapy, 2020 - Springer
Background Treatments are needed to address the growing prevalence of Alzheimer's
disease (AD). Clinical trials have failed to produce any AD drugs for Food and Drug …
disease (AD). Clinical trials have failed to produce any AD drugs for Food and Drug …
Topological network measures for drug repositioning
A Badkas, S De Landtsheer… - Briefings in bioinformatics, 2021 - academic.oup.com
Drug repositioning has received increased attention since the past decade as several
blockbuster drugs have come out of repositioning. Computational approaches are …
blockbuster drugs have come out of repositioning. Computational approaches are …
Computational drug repurposing by exploiting large-scale gene expression data: Strategy, methods and applications
H He, H Duo, Y Hao, X Zhang, X Zhou, Y Zeng… - Computers in biology …, 2023 - Elsevier
De novo drug development is an extremely complex, time-consuming and costly task.
Urgent needs for therapies of various diseases have greatly accelerated searches for more …
Urgent needs for therapies of various diseases have greatly accelerated searches for more …
[HTML][HTML] Deficiency of autism-related Scn2a gene in mice disrupts sleep patterns and circadian rhythms
Autism spectrum disorder (ASD) affects~ 2% of the population in the US, and monogenic
forms of ASD often result in the most severe manifestation of the disorder. Recently, SCN2A …
forms of ASD often result in the most severe manifestation of the disorder. Recently, SCN2A …
[HTML][HTML] Pathophysiology of fibrosis in the vocal fold: current research, future treatment strategies, and obstacles to restoring vocal fold pliability
Y Kumai - International journal of molecular sciences, 2019 - mdpi.com
Communication by voice depends on symmetrical vibrations within the vocal folds (VFs) and
is indispensable for various occupations. VF scarring is one of the main reasons for …
is indispensable for various occupations. VF scarring is one of the main reasons for …
Drug repositioning: current approaches and their implications in the precision medicine era
A Talevi - Expert Review of Precision Medicine and Drug …, 2018 - Taylor & Francis
Introduction: Drug repositioning implies finding new medical uses for existing drugs. It
represents a cost-efficient approach, since the new indications are built on the basis of …
represents a cost-efficient approach, since the new indications are built on the basis of …
[HTML][HTML] Computational drug repurposing for Alzheimer's disease using risk genes from GWAS and single-cell RNA sequencing studies
Background: Traditional therapeutics targeting Alzheimer's disease (AD)-related
subpathologies have so far proved ineffective. Drug repurposing, a more effective strategy …
subpathologies have so far proved ineffective. Drug repurposing, a more effective strategy …
Sex‐specific declines in cholinergic‐targeting tRNA fragments in the nucleus accumbens in Alzheimer's disease
Abstract Introduction Females with Alzheimer's disease (AD) suffer accelerated dementia
and loss of cholinergic neurons compared to males, but the underlying mechanisms are …
and loss of cholinergic neurons compared to males, but the underlying mechanisms are …