This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Twenty years ago, Rho-kinase was identified as an important downstream effector of the
small GTP-binding protein, RhoA. Thereafter, a series of studies demonstrated the important …

Rho-associated coiled-coil containing kinases (ROCK) were originally identified as effectors
of the RhoA small GTPase.–They belong to the AGC family of serine/threonine kinases and …

Rho-associated kinases ROCK1 and ROCK2 are serine/threonine kinases that are
downstream targets of the small GTPases RhoA, RhoB, and RhoC. ROCKs are involved in …

Several lines of evidence suggest that mitochondrial dysfunction plays a critical role in the
pathogenesis of microvascular complications of diabetes, including diabetic nephropathy …

Rho-associated kinases ROCK1 and ROCK2 are key regulators of actin cytoskeleton
dynamics downstream of Rho GTPases that participate in the control of important …

Rho GTPase is a master regulator controlling cytoskeleton in multiple contexts such as cell
migration, adhesion and cytokinesis. Of several Rho GTPases in mammals, the best …

Abstract The small GTPase RhoA and its downstream effectors, ROCK1 and ROCK2,
regulate a number of cellular processes, including cell motility, proliferation, survival, and …

Abstract The small Rho GTPase family of proteins, encompassing the three major G-protein
classes Rho, Rac and cell division control protein 42, are key mitogenic signaling molecules …

Deregulated production of IL-17 and IL-21 plays a key pathogenic role in many autoimmune
disorders. A delineation of the mechanisms that underlie the inappropriate synthesis of IL-17 …