Transcriptome studies reveal pervasive transcription of complex genomes, such as those of
mammals. Despite popular arguments for functionality of most, if not all, of these transcripts …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

The Ensembl gene annotation system has been used to annotate over 70 different
vertebrate species across a wide range of genome projects. Furthermore, it generates the …

INTRODUCTION In animals, gene regulatory networks specify cell identity in space and
time. Transcription of genes in these networks is modulated by a class of cis-regulatory …

Summary cis-regulatory changes play a central role in morphological divergence, yet the
regulatory principles underlying emergence of human traits remain poorly understood. Here …

Human higher cognition is attributed to the evolutionary expansion and elaboration of the
human cerebral cortex. However, the genetic mechanisms contributing to these …

Enhancers are genomic DNA elements controlling spatiotemporal gene expression. Their
flexible organization and functional redundancies make deciphering their sequence-function …

Understanding the roles of noncoding RNAs (ncRNA) in tumorigenesis and metastasis
would establish novel avenues to identify diagnostic and therapeutic targets. Here, we …

Non-coding cis-regulatory variants in animal genomes are an important driving force in the
evolution of transcription regulation and phenotype diversity. However, cistrome dynamics in …

To gain insight into how mammalian gene expression is controlled by rapidly evolving
regulatory elements, we jointly analysed promoter and enhancer activity with downstream …