Surface curvature both emerges from, and influences the behavior of, living objects at length
scales ranging from cell membranes to single cells to tissues and organs. The relevance of …

Stem cells and their local microenvironment, or niche, communicate through mechanical
cues to regulate cell fate and cell behaviour and to guide developmental processes. During …

Time-lapse, deep-tissue imaging made possible by advances in intravital microscopy has
demonstrated the importance of tumour cell migration through confining tracks in vivo. These …

During metazoan development, immune surveillance and cancer dissemination, cells
migrate in complex three-dimensional microenvironments,–. These spaces are crowded by …

Cell migration has two opposite faces: although necessary for physiological processes such
as immune responses, it can also have detrimental effects by enabling metastatic cells to …

G-protein-coupled receptors (GPCRs) mediate many critical physiological processes. Their
spatial organization in plasma membrane (PM) domains is believed to encode signaling …

The interrelationship between microtubules and the actin cytoskeleton in
mechanoregulation of integrin-mediated adhesions is poorly understood. Here, we show …

The importance of curvature as a structural feature of biological membranes has been
recognized for many years and has fascinated scientists from a wide range of different …

Actomyosin contractility plays a central role in a wide range of cellular processes, including
the establishment of cell polarity, cell migration, tissue integrity, and morphogenesis during …

The morphogenesis of branched organs remains a subject of abiding interest. Although
much is known about the underlying signaling pathways, it remains unclear how …