Liposomes: Structure, composition, types, and clinical applications

H Nsairat, D Khater, U Sayed, F Odeh, A Al Bawab… - Heliyon, 2022 - cell.com
Liposomes are now considered the most commonly used nanocarriers for various potentially
active hydrophobic and hydrophilic molecules due to their high biocompatibility …

Production, characterization, delivery, and cholesterol-lowering mechanism of phytosterols: a review

R Zhang, Y Han, DJ McClements, D Xu… - Journal of agricultural …, 2022 - ACS Publications
Phytosterols are natural plant-based bioactive compounds that can lower blood cholesterol
levels and help prevent cardiovascular diseases. Consequently, they are being utilized in …

Deconvoluting lipid nanoparticle structure for messenger RNA delivery

Y Eygeris, S Patel, A Jozic, G Sahay - Nano letters, 2020 - ACS Publications
Lipid nanoparticle (LNP) packaged mRNA vaccines have been deployed against infectious
diseases such as COVID-19, yet their structural features remain unclear. Cholesterol, a …

Liposomes for drug delivery: review of vesicular composition, factors affecting drug release and drug loading in liposomes

S Pande - Artificial Cells, Nanomedicine, and Biotechnology, 2023 - Taylor & Francis
Liposomes are considered among the most versatile and advanced nanoparticle delivery
systems used to target drugs to specific cells and tissues. Structurally, liposomes are sphere …

Basic methods for preparation of liposomes and studying their interactions with different compounds, with the emphasis on polyphenols

L Šturm, N Poklar Ulrih - International journal of molecular sciences, 2021 - mdpi.com
Studying the interactions between lipid membranes and various bioactive molecules (eg,
polyphenols) is important for determining the effects they can have on the functionality of …

Modification of lipid-based nanoparticles: An efficient delivery system for nucleic acid-based immunotherapy

C Zhang, Y Ma, J Zhang, JCT Kuo, Z Zhang, H Xie… - Molecules, 2022 - mdpi.com
Lipid-based nanoparticles (LBNPs) are biocompatible and biodegradable vesicles that are
considered to be one of the most efficient drug delivery platforms. Due to the prominent …

Box–Behnken design of thermo-responsive nano-liposomes loaded with a platinum (IV) anticancer complex: evaluation of cytotoxicity and apoptotic pathways in triple …

NK Sedky, M Braoudaki, NK Mahdy, K Amin… - Nanoscale …, 2023 - pubs.rsc.org
Herein, thermo-responsive liposomes (TLs) loaded with Asp (Asp/TLs) were produced by
self-assembling DPPC, DSPE-PEG2000, and cholesterol. The preparation variables were …

High‐Precision Synthesis of RNA‐Loaded Lipid Nanoparticles for Biomedical Applications

H Seo, L Jeon, J Kwon, H Lee - Advanced Healthcare …, 2023 - Wiley Online Library
The recent development of RNA‐based therapeutics in delivering nucleic acids for gene
editing and regulating protein translation has led to the effective treatment of various …

Liposome bilayer stability: Emphasis on cholesterol and its alternatives

H Nsairat, AA Ibrahim, AM Jaber… - Journal of Liposome …, 2024 - Taylor & Francis
Liposomes are spherical lipidic nanocarriers composed of natural or synthetic phospholipids
with a hydrophobic bilayer and aqueous core, which are arranged into a polar head and a …

Preparation of nanoliposomes by microfluidic mixing in herring-bone channel and the role of membrane fluidity in liposomes formation

J Kotouček, F Hubatka, J Mašek, P Kulich, K Velínská… - Scientific reports, 2020 - nature.com
Introduction of microfluidic mixing technique opens a new door for preparation of the
liposomes and lipid-based nanoparticles by on-chip technologies that are applicable in a …