Highlights•NLRP1 is a sensor of diverse pathogen-encoded activities.•'Functional
degradation'provides a mechanism for NLRP1 activation.•New insights into NLRP1 have …

The oncogenic epithelial–mesenchymal transition (EMT) contributes to tumor progression in
various context-dependent ways, including increased metastatic potential, expansion of …

Nucleotide-binding domain and leucine-rich repeat pyrin-domain containing protein 1
(NLRP1) is an inflammasome sensor that mediates the activation of caspase-1 to induce …

Nucleotide-binding domain, leucine-rich repeat receptors (NLRs) mediate innate immunity
by forming inflammasomes. Activation of the NLR protein NLRP1 requires autocleavage …

Endothelial cells (ECs) form extensive, highly branched and hierarchically organized tubular
networks in vertebrates to ensure the proper distribution of molecular and cellular cargo in …

Blood-brain barrier (BBB) integrity is critical for proper function of the central nervous system
(CNS). Here, we show that the endothelial Unc5B receptor controls BBB integrity by …

Over the past few years, several genes, proteins and signalling pathways that are required
for embryogenesis have been shown to regulate tumour development and progression by …

The “Function to Find Domain”(FIIND)-containing proteins CARD8 (Cardinal; Tucan) and
NLRP1 (NALP1; NAC) are well known components of inflammasomes, multiprotein …

Neurons are highly specialized cells of the nervous system that receive, process and
transmit electrical signals critical for normal brain function. Here, we review the intricate …

Dependence receptors (DRs) now form a family of more than a dozen membrane receptors
that are not linked by their structure, but by common functional traits. The most notable is …