Objectives To systematically review findings of GWAS in schizophrenia (SZ) and in bipolar
disorder (BD); and to interpret findings, with a focus on identifying independent replications …

VRK1 is a nuclear Ser-Thr chromatin kinase that does not mutate in cancer, and is
overexpressed in many types of tumors and associated with a poor prognosis. Chromatin …

Eukaryotic cells store their chromosomes in a single nucleus. This is important to maintain
genomic integrity, as chromosomes packaged into separate nuclei (micronuclei) are prone …

Common sequence variants have recently joined rare structural polymorphisms as genetic
factors with strong evidence for association with schizophrenia. Here we extend our …

Synthetic lethality is a genetic interaction that results in cell death when two genetic
deficiencies co-occur but not when either deficiency occurs alone, which can be co-opted for …

About 10% of all protein kinases are predicted to be enzymatically inactive pseudokinases,
but the structural details of kinase inactivation have remained unclear. We present the first …

SOX2 is a key transcription factor that plays critical roles in maintaining stem cell property
and conferring drug resistance. However, the underlying mechanisms by which SOX2 level …

Collateral lethality occurs when loss of a gene/protein renders cancer cells dependent on its
remaining paralog. Combining genome-scale CRISPR/Cas9 loss-of-function screens with …

Cancer remains the second leading cause of death in the US, accounting for 25% of all
deaths nationwide. Immunotherapy techniques bolster the immune cells' ability to target …

The search for oncogenes is becoming increasingly important in cancer genetics because
they are suitable targets for therapeutic intervention. To identify novel oncogenes, activated …