Nonalcoholic fatty liver disease (NAFLD) is the liver manifestation of metabolic syndrome
and is the most common chronic liver disease in the world. The pathogenesis of NAFLD has …

The beta-cell identity gene, pancreatic duodenal homeobox 1 (Pdx1), plays critical roles in
many aspects of the life of beta-cells including differentiation, maturation, function, survival …

During aging, muscle gradually undergoes sarcopenia, the loss of function associated with
loss of mass, strength, endurance, and oxidative capacity. However, the 3D structural …

Background: Hepatocellular Carcinoma (HCC) is a major form of liver cancer and a leading
cause of cancer-related death worldwide. New insights into HCC pathobiology and …

Background Sodium–glucose cotransporter 2 (SGLT2) inhibitors constitute the gold
standard treatment for type 2 diabetes mellitus (T2DM). Among them, empagliflozin (EMPA) …

Insulin resistance is present in one-quarter of the general population, predisposing these
people to a wide range of diseases. Our aim was to identify cell-intrinsic determinants of …

Abstract Alisol B 23-acetate (AB23A) is a natural triterpenoid isolated from Rhizoma
alisamatis that has been widely used as a traditional Chinese medicine (TCM). Previous …

Pancreatic β-cell dysfunction and insulin resistance are two of the major causes of type 2
diabetes (T2D). Recent clinical and experimental studies have suggested that the functional …

Glucose homeostasis is the maintenance and regulation of blood glucose concentration
within a tight physiological range, essential for the functioning of most tissues and organs …

Parkinson's disease (PD) is the second most frequent neurodegenerative disease. It is
characterized by the loss of dopaminergic neurons in the substantia nigra and the formation …