Acquisition of the arterial and haemogenic endothelium fates concurrently occur in the aorta–
gonad–mesonephros (AGM) region prior to haematopoietic stem cell (HSC) generation. The …

Notch signaling is necessary for the development of many organ systems, including the
nervous system, biliary system, and visual and auditory sensory systems. This signaling …

Although Notch1 and Notch2 are closely related paralogs and function through the same
canonical signaling pathway, they contribute to different outcomes in some cell and disease …

Notch signaling controls proliferation of multipotent pancreatic progenitor cells (MPCs) and
their segregation into bipotent progenitors (BPs) and unipotent pro-acinar cells (PACs) …

An ascending aortic aneurysm (AscAA) is a life-threatening disease whose molecular basis
is poorly understood. Mutations in NOTCH1 have been linked to bicuspid aortic valve (BAV) …

The cortical and medullary thymic epithelial cell (cTEC and mTEC) lineages are essential for
inducing T cell lineage commitment, T cell positive selection and the establishment of self …

Notch-mediated lateral specification is a fundamental mechanism to resolve stochastic cell
fate choices by amplifying initial differences between equivalent cells. To study how …

Background Notch signaling pathway is involved in contact‐dependent communication
between the cells of seminiferous epithelium, and its proper activity is important for …

Coordination of cell proliferation and migration is fundamental for life, and its dysregulation
has catastrophic consequences, such as cancer. How cell cycle progression affects …

Rationale: Ventricular arrhythmias often arise from the Purkinje–myocyte junction and are a
leading cause of sudden cardiac death. Notch activation reprograms cardiac myocytes to an …