Biologists have long been intrigued by the possibility that cells can change their identity, a
phenomenon known as cellular plasticity. The discovery that terminally differentiated cells …

Tissue injury initiates a complex repair process, which in some organisms can lead to the
complete regeneration of a tissue. In mammals, however, the repair of most organs is …

The failure to replace damaged body parts in adult mammals results from a muted growth
response and fibrotic scarring. Although infiltrating immune cells play a major role in …

In contrast to non-mammalian vertebrates, mammals and humans have limited innate
capacity for the self-regeneration of tissues and organs owing to differences in genetics …

Stimulating regeneration of complex tissues and organs after injury to effect complete
structural and functional repair, is an attractive therapeutic option that would revolutionize …

Activation of the immune response during injury is a critical early event that determines
whether the outcome of tissue restoration is regeneration or replacement of the damaged …

Adult zebrafish generate new neurons in the brain and retina throughout life. Growth-related
neurogenesis allows a vigorous regenerative response to damage, and fish can regenerate …

Planarians are members of the Platyhelminthes (flatworms). These animals have evolved a
remarkable stem cell system. A single pluripotent adult stem cell type (“neoblast”) gives rise …

Fibrotic disorders account for an increasing burden of disease-associated morbidity and
mortality worldwide. Although numerous risk factors have been recognized, the etiologies of …

Cardiovascular disease is the leading cause of death worldwide. Compared to other organs
such as the liver, the adult human heart lacks the capacity to regenerate on a macroscopic …