T cells engineered to express chimeric antigen receptors (CARs) that are specific for tumour
antigens have led to high complete response rates in patients with haematologic …

Chimeric antigen receptor (CAR)-engineered T cells (CAR-T cells) have yielded
unprecedented efficacy in B cell malignancies, most remarkably in anti-CD19 CAR-T cells …

Adoptive cell therapy (ACT) is a kind of immunotherapy in which T cells are genetically
modified to express a chimeric antigen receptor (CAR) or T cell receptor (TCR), and ACT …

Synthetic biology aims to design or assemble existing bioparts or bio-components for useful
bioproperties. During the past decades, progresses have been made to build delicate …

Chimeric antigen receptor T (CAR-T) cell therapy is a promising and precise targeted
therapy for cancer that has demonstrated notable potential in clinical applications. However …

On-target off-tumour toxicity limits the anticancer applicability of chimaeric antigen receptor
(CAR) T cells. Here we show that the tumour-targeting specificity and activity of T cells with a …

Antibody has become the most rapidly expanding class of pharmaceuticals for treating a
wide variety of human diseases including cancers. Especially, with the fast development of …

Objective Pancreatic ductal adenocarcinoma (PDAC) is a disease of unmet medical need.
While immunotherapy with chimeric antigen receptor T (CAR-T) cells has shown much …

Virtually all natural proteins are built from only 20 amino acids, and while this makes
possible all the functions they perform, the ability to encode other amino acids selected for …

We developed a new method for the conditional regulation of CRISPR/Cas9 activity in
mammalian cells and zebrafish embryos using photochemically activated, caged guide …