Mammalian sperm cells must respond to cues originating from along the female
reproductive tract and from the layers of the egg in order to complete their fertilization …

Fertilization is defined as the union of two gametes. During fertilization, sperm and egg fuse
to form a diploid zygote to initiate prenatal development. In mammals, fertilization involves …

Precise signalling between pollen tubes and synergid cells in the ovule initiates fertilization
in flowering plants. Contact of the pollen tube with the ovule triggers calcium spiking in the …

The reaction of CO2 with H2O to form bicarbonate (HCO3−) and H+ controls sperm motility
and fertilization via HCO3−-stimulated cAMP synthesis. A complex network of signaling …

The cation channel of sperm (CatSper) is essential for sperm motility and fertility,. CatSper
comprises the pore-forming proteins CATSPER1–4 and multiple auxiliary subunits …

Sperm motility is linked to the activation of signaling pathways that trigger movement. These
pathways are mainly dependent on Ca2+, which acts as a secondary messenger. The …

The infertility of many couples rests on an enigmatic dysfunction of the man's sperm. To gain
insight into the underlying pathomechanisms, we assessed the function of the sperm …

BACKGROUND Intensive research on sperm ion channels has identified members of
several ion channel families in both mouse and human sperm. Gene knock-out studies have …

Abstract Calcium ions (Ca 2+) are involved in nearly every aspect of cellular life. They are
one of the most abundant elements in mammals and play a vital role in physiological and …

Tumor cells and surrounding immune cells undergo metabolic reprogramming, leading to an
acidic tumor microenvironment. However, it is unclear how tumor cells adapt to this acidic …