Beyond sequencing: machine learning algorithms extract biology hidden in Nanopore signal data

YK Wan, C Hendra, PN Pratanwanich, J Göke - Trends in Genetics, 2022 - cell.com
Nanopore sequencing provides signal data corresponding to the nucleotide motifs
sequenced. Through machine learning-based methods, these signals are translated into …

The international society of RNA nanotechnology and nanomedicine (ISRNN): the present and future of the burgeoning field

M Chandler, B Johnson, E Khisamutdinov… - ACS …, 2021 - ACS Publications
The International Society of RNA Nanotechnology and Nanomedicine (ISRNN) hosts an
annual meeting series focused on presenting the latest research achievements involving …

The m6A reader YTHDC2 is essential for escape from KSHV SOX-induced RNA decay

D Macveigh-Fierro, A Cicerchia… - Proceedings of the …, 2022 - National Acad Sciences
The role of N6-methyladenosine (m6A) modifications has increasingly been associated with
a diverse set of roles in modulating viruses and influencing the outcomes of viral infection …

Functional and molecular dissection of HCMV long non-coding RNAs

S Lee, H Kim, A Hong, J Song, S Lee, M Kim… - Scientific Reports, 2022 - nature.com
Small, compact genomes confer a selective advantage to viruses, yet human
cytomegalovirus (HCMV) expresses the long non-coding RNAs (lncRNAs); RNA1. 2, RNA2 …

N 6 -Methyladenosine and Its Implications in Viruses

Y Wang, X Zhou - Genomics, Proteomics & Bioinformatics, 2023 - academic.oup.com
Abstract N 6-methyladenine (m6A) is the most abundant RNA modification in mammalian
messenger RNAs (mRNAs), which participates in and regulates many important biological …

METTL16 controls Kaposi's sarcoma-associated herpesvirus replication by regulating S-adenosylmethionine cycle

X Zhang, W Meng, J Feng, X Gao, C Qin, P Feng… - Cell Death & …, 2023 - nature.com
Oncogenic Kaposi's sarcoma-associated herpesvirus (KSHV) consists of latent and lytic
replication phases, both of which are important for the development of KSHV-related …

Inhibition of RNA binding in SND1 increases the levels of miR-1-3p and sensitizes cancer cells to navitoclax

S Lehmusvaara, T Haikarainen, J Saarikettu… - Cancers, 2022 - mdpi.com
Simple Summary Despite of decades of intensive research, several cancer types, for
example aggressive colon cancers, are still difficult to treat, and life expectancy is low. Since …

[HTML][HTML] Multilevel regulation of N6-methyladenosine RNA modifications: Implications in tumorigenesis and therapeutic opportunities

L Feng, R Du, B Chang, M Li, J Tian, S Wang - Genes & Diseases, 2023 - Elsevier
Abstract N 6-methyladenosine (m 6 A) RNA modification is widely perceived as the most
abundant and common modification in transcripts. This modification is dynamically regulated …

Comprehensive analysis of long non-coding RNA expression profiles of GC-1spg cells with m6A methylation knockdown

D Zhong, C Yao, L Zhang, J Wang, Q Liu, D Shi… - Gene, 2023 - Elsevier
Spermatogenesis is a complex process that requires many regulatory mechanisms to form
healthy sperm. Numerous studies have also proved that m6A methylation modification and …

INVESTIGATING THE ESCAPE MECHANISM OF SRE BEARING MRNA TRANSCRIPTS DURING VIRAL HOST SHUTOFF

D MacVeigh-Fierro - 2024 - scholarworks.umass.edu
During viral infection, the virus and host clash for control over gene expression in an
evolutionarily arms race that has raged for thousands of years. During lytic replication …