Sex and the singular DM domain: insights into sexual regulation, evolution and plasticity

CK Matson, D Zarkower - Nature Reviews Genetics, 2012 - nature.com
Most animals reproduce sexually, but the genetic and molecular mechanisms that determine
the eventual sex of each embryo vary remarkably. DM domain genes, which are related to …

Dmrt genes in the development and evolution of sexual dimorphism

A Kopp - Trends in Genetics, 2012 - cell.com
Most animals are sexually dimorphic, but different taxa have different sex-specific traits.
Despite major differences in the genetic control of sexual development among animal …

Dmrt1, a gene related to worm and fly sexual regulators, is required for mammalian testis differentiation

CS Raymond, MW Murphy, MG O'Sullivan… - Genes & …, 2000 - genesdev.cshlp.org
The only molecular similarity in sex determination found so far among phyla is between the
Drosophila doublesex (dsx) and Caenorhabditis elegans mab-3 genes. dsx and mab-3 …

Evidence for evolutionary conservation of sex-determining genes

CS Raymond, CE Shamu, MM Shen, KJ Seifert… - Nature, 1998 - nature.com
Most metazoans occur as two sexes. Surprisingly, molecular analyses have hitherto
indicated that sex-determining mechanisms differ completely between phyla. Here we …

A W-linked DM-domain gene, DM-W, participates in primary ovary development in Xenopus laevis

S Yoshimoto, E Okada, H Umemoto… - Proceedings of the …, 2008 - National Acad Sciences
In the XX/XY sex-determining system, the Y-linked SRY genes of most mammals and the
DMY/Dmrt1bY genes of the teleost fish medaka have been characterized as sex …

Transition metals in control of gene expression

TV O'Halloran - Science, 1993 - science.org
Metalloproteins play structural and catalytic roles in gene expression. The metalloregulatory
proteins are a subclass that exerts metal-responsive control of genes involved in respiration …

[PDF][PDF] fruitless splicing specifies male courtship behavior in Drosophila

E Demir, BJ Dickson - Cell, 2005 - cell.com
All animals exhibit innate behaviors that are specified during their development. Drosophila
melanogaster males (but not females) perform an elaborate and innate courtship ritual …

The evolution of signalling pathways in animal development

A Pires-daSilva, RJ Sommer - Nature Reviews Genetics, 2003 - nature.com
Despite the bewildering number of cell types and patterns found in the animal kingdom, only
a few signalling pathways are required to generate them. Most cell–cell interactions during …

Vive la difference: males vs females in flies vs worms

TW Cline, BJ Meyer - Annual review of genetics, 1996 - annualreviews.org
▪ Abstract For 600 million years, the two best-understood metazoan species, the nematode
Caenorhabditis elegans and the fruit fly Drosophila melanogaster, have developed …

Expression of Dmrt1 in the genital ridge of mouse and chicken embryos suggests a role in vertebrate sexual development

CS Raymond, JR Kettlewell, B Hirsch, VJ Bardwell… - Developmental …, 1999 - Elsevier
Sex-determining mechanisms are highly variable between phyla. Only one example has
been found in which structurally and functionally related genes control sex determination in …