Twist is a critical epithelial–mesenchymal transition (EMT)–inducing transcription factor that
increases expression of vimentin. How Twist1 regulates this expression remains unclear …

ABSTRACT A low level of tissue oxygen (hypoxia) is a physiological feature of a wide range
of diseases, from cancer to infection. Cellular hypoxia is sensed by oxygen-sensitive …

With the advent of genetic engineering, zebrafish (Danio rerio) were recognized as an
attractive model organism to study many biological processes. Remarkably, the small size …

The transition to air breathing after birth requires both anatomic and biochemical maturation
of the lung. Lung morphogenesis is mediated by complex paracrine interactions between …

The discovery of microRNAs (miRNAs) provides a new and powerful tool for studying the
mechanisms, diagnosis and treatments of cancer. In this study, we employed AFFX miRNA …

Abstract Cullin-Ring E3 Ligases (CRLs) regulate a multitude of cellular pathways through
specific substrate receptors. The COP9 signalosome (CSN) deactivates CRLs by removing …

MicroRNAs (miRNAs) serve important roles in drug‑resistance; however, exosomal miRNAs
associated with drug‑resistance in ovarian cancer (OC) have not been reported to date. The …

Neuroendocrine neoplasms (NENs) comprise a heterogeneous group of rare malignancies,
mainly originating from hormone-secreting cells, which are widespread in human tissues …

Background The commercial production of Atlantic halibut (Hippoglossus hippoglossus L.)
suffers from a major bottleneck due to the low success of producing juveniles for on-growing …

Better understanding alveolarization mechanisms could help improve prevention and
treatment of diseases characterized by reduced alveolar number. Although signaling …