Targeting inflammation in atherosclerosis—from experimental insights to the clinic

O Soehnlein, P Libby - Nature reviews Drug discovery, 2021 - nature.com
Atherosclerosis, a dominant and growing cause of death and disability worldwide, involves
inflammation from its inception to the emergence of complications. Targeting inflammatory …

Gut microbiome–brain alliance: a landscape view into mental and gastrointestinal health and disorders

JM Sasso, RM Ammar, R Tenchov… - ACS Chemical …, 2023 - ACS Publications
Gut microbiota includes a vast collection of microorganisms residing within the
gastrointestinal tract. It is broadly recognized that the gut and brain are in constant …

Gut microbiota and cardiovascular disease

M Witkowski, TL Weeks, SL Hazen - Circulation research, 2020 - Am Heart Assoc
Fecal microbial community changes are associated with numerous disease states, including
cardiovascular disease (CVD). However, such data are merely associative. A causal …

NAFLD and increased risk of cardiovascular disease: clinical associations, pathophysiological mechanisms and pharmacological implications

G Targher, CD Byrne, H Tilg - Gut, 2020 - gut.bmj.com
Non-alcoholic fatty liver disease (NAFLD) is a public health problem, affecting up to a third of
the world's adult population. Several cohort studies have consistently documented that …

Multiple parallel hits hypothesis in nonalcoholic fatty liver disease: revisited after a decade

H Tilg, TE Adolph, AR Moschen - Hepatology, 2021 - journals.lww.com
Nonalcoholic fatty liver disease (NAFLD) is an epidemic liver disease, affecting
approximately one quarter of the entire population in the world.(1) This disease …

Western diets and chronic diseases

TE Adolph, H Tilg - Nature medicine, 2024 - nature.com
Abstract 'Westernization', which incorporates industrial, cultural and dietary trends, has
paralleled the rise of noncommunicable diseases across the globe. Today, the Western-style …

Influence of the gut microbiome, diet, and environment on risk of colorectal cancer

M Song, AT Chan, J Sun - Gastroenterology, 2020 - Elsevier
Researchers have discovered associations between elements of the intestinal microbiome
(including specific microbes, signaling pathways, and microbiota-related metabolites) and …

[HTML][HTML] Functions of gut microbiota metabolites, current status and future perspectives

J Liu, Y Tan, H Cheng, D Zhang, W Feng… - Aging and …, 2022 - ncbi.nlm.nih.gov
Gut microbiota, a collection of microorganisms that live within gastrointestinal tract, provides
crucial signaling metabolites for the physiological of hosts. In healthy state, gut microbiota …

[HTML][HTML] Trimethylamine N-oxide (TMAO) in human health

P Gatarek, J Kaluzna-Czaplinska - EXCLI journal, 2021 - ncbi.nlm.nih.gov
Due to numerous links between trimethylamine-N-oxide (TMAO) and various disorders and
diseases, this topic is very popular and is often taken up by researchers. TMAO is a low …

Food as medicine: targeting the uraemic phenotype in chronic kidney disease

D Mafra, NA Borges, B Lindholm, PG Shiels… - Nature Reviews …, 2021 - nature.com
The observation that unhealthy diets (those that are low in whole grains, fruits and
vegetables, and high in sugar, salt, saturated fat and ultra-processed foods) are a major risk …