Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?

P Rada, Á González-Rodríguez, C García-Monzón… - Cell death & …, 2020 - nature.com
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease
worldwide. NAFLD stages range from simple steatosis (NAFL) to non-alcoholic …

The role of peroxisome proliferator-activated receptors (PPAR) in immune responses

A Christofides, E Konstantinidou, C Jani, VA Boussiotis - Metabolism, 2021 - Elsevier
Peroxisome proliferator-activated receptors (PPARs) are fatty acid-activated transcription
factors of nuclear hormone receptor superfamily that regulate energy metabolism. Currently …

Molecular Actions of PPARα in Lipid Metabolism and Inflammation

N Bougarne, B Weyers, SJ Desmet, J Deckers… - Endocrine …, 2018 - academic.oup.com
Peroxisome proliferator–activated receptor α (PPAR α) is a nuclear receptor of clinical
interest as a drug target in various metabolic disorders. PPAR α also exhibits marked anti …

[HTML][HTML] Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease

M Pawlak, P Lefebvre, B Staels - Journal of hepatology, 2015 - Elsevier
Peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription
factor belonging, together with PPARγ and PPARβ/δ, to the NR1C nuclear receptor …

Mechanisms mediating the regulation of peroxisomal fatty acid beta-oxidation by PPARα

M Tahri-Joutey, P Andreoletti, S Surapureddi… - International journal of …, 2021 - mdpi.com
In mammalian cells, two cellular organelles, mitochondria and peroxisomes, share the ability
to degrade fatty acid chains. Although each organelle harbors its own fatty acid β-oxidation …

CD36 as a gatekeeper of myocardial lipid metabolism and therapeutic target for metabolic disease

JFC Glatz, LC Heather… - Physiological reviews, 2024 - journals.physiology.org
The multifunctional membrane glycoprotein CD36 is expressed in different types of cells and
plays a key regulatory role in cellular lipid metabolism, especially in cardiac muscle. CD36 …

Regulation of energy metabolism by long-chain fatty acids

MT Nakamura, BE Yudell, JJ Loor - Progress in lipid research, 2014 - Elsevier
In mammals, excess energy is stored primarily as triglycerides, which are mobilized when
energy demands arise. This review mainly focuses on the role of long chain fatty acids …

[HTML][HTML] Integrated physiology and systems biology of PPARα

S Kersten - Molecular metabolism, 2014 - Elsevier
Abstract The Peroxisome Proliferator Activated Receptor alpha (PPARα) is a transcription
factor that plays a major role in metabolic regulation. This review addresses the functional …

PPARs and nonalcoholic fatty liver disease

KHH Liss, BN Finck - Biochimie, 2017 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) encompasses a range of liver pathology ranging
from simple steatosis to varying degrees of inflammation, hepatocyte injury and fibrosis …

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

T Yamauchi, J Kamon, H Waki, Y Terauchi, N Kubota… - Nature medicine, 2001 - nature.com
Adiponectin is an adipocyte-derived hormone. Recent genome-wide scans have mapped a
susceptibility locus for type 2 diabetes and metabolic syndrome to chromosome 3q27, where …