The Hippo signaling network and its biological functions
Hippo signaling is an evolutionarily conserved network that has a central role in regulating
cell proliferation and cell fate to control organ growth and regeneration. It promotes …
cell proliferation and cell fate to control organ growth and regeneration. It promotes …
Regulation of body size and growth control
The control of body and organ growth is essential for the development of adults with proper
size and proportions, which is important for survival and reproduction. In animals, adult body …
size and proportions, which is important for survival and reproduction. In animals, adult body …
Mechanical control of growth: ideas, facts and challenges
KD Irvine, BI Shraiman - Development, 2017 - journals.biologists.com
In his classic book On Growth and Form, D'Arcy Thompson discussed the necessity of a
physical and mathematical approach to understanding the relationship between growth and …
physical and mathematical approach to understanding the relationship between growth and …
MRTF potentiates TEAD‐YAP transcriptional activity causing metastasis
Yes‐associated protein (YAP) and myocardin‐related transcription factor (MRTF) play
similar roles and exhibit significant crosstalk in directing transcriptional responses to …
similar roles and exhibit significant crosstalk in directing transcriptional responses to …
Roles of the insulin signaling pathway in insect development and organ growth
X Lin, G Smagghe - Peptides, 2019 - Elsevier
Organismal development is a complex process as it requires coordination of many aspects
to grow into fit individuals, such as the control of body size and organ growth. Therefore, the …
to grow into fit individuals, such as the control of body size and organ growth. Therefore, the …
Evolutionary genomics of camouflage innovation in the orchid mantis
The orchid mantises achieve camouflage with morphological modifications in body color
and pattern, providing an interesting model for understanding phenotypic innovation …
and pattern, providing an interesting model for understanding phenotypic innovation …
Usp7 regulates Hippo pathway through deubiquitinating the transcriptional coactivator Yorkie
X Sun, Y Ding, M Zhan, Y Li, D Gao, G Wang… - Nature …, 2019 - nature.com
The Hippo pathway plays an important role in organ development and adult tissue
homeostasis, and its deregulation has been implicated in many cancers. The Hippo …
homeostasis, and its deregulation has been implicated in many cancers. The Hippo …
Active N6-methyladenine demethylation by DMAD regulates gene expression by coordinating with polycomb protein in neurons
A ten-eleven translocation (TET) ortholog exists as a DNA N 6-methyladenine (6mA)
demethylase (DMAD) in Drosophila. However, the molecular roles of 6mA and DMAD …
demethylase (DMAD) in Drosophila. However, the molecular roles of 6mA and DMAD …
An ectopic network of transcription factors regulated by hippo signaling drives growth and invasion of a malignant tumor model
Cancer cells have abnormal gene expression profiles; however, to what degree these are
chaotic or driven by structured gene regulatory networks is often not known. Here we studied …
chaotic or driven by structured gene regulatory networks is often not known. Here we studied …
A Dilp8-dependent time window ensures tissue size adjustment in Drosophila
D Blanco-Obregon, K El Marzkioui, F Brutscher… - Nature …, 2022 - nature.com
The control of organ size mainly relies on precise autonomous growth programs. However,
organ development is subject to random variations, called developmental noise, best …
organ development is subject to random variations, called developmental noise, best …