CuAAC chemistry is used to compose incredible synthetic molecular architectures and acts
as a true click chemistry reaction allowing densely functional molecular fragments to be …

The cyclization reactions of alkynes have become one of the most important and useful
methodologies for the preparation of heterocycles. To this end, the association between …

The Cu-catalyzed azide–alkyne cycloaddition (CuAAC) reaction is used as a ligation tool
throughout chemical and biological sciences. Despite the pervasiveness of CuAAC, there is …

The Cu-catalyzed azide–alkyne cycloaddition (CuAAC) reaction is a key ligation tool used to
prepare bioconjugates. Despite the widespread utility of CuAAC to produce discrete 1, 4 …

Traditional approaches to bio‐orthogonal reaction discovery have focused on developing
reagent pairs that react with each other faster than they are metabolically degraded …

Metal-catalyzed cycloaddition is an expeditious synthetic route to functionalized heterocyclic
frameworks. However, achieving reactivity-controlled metal-catalyzed azide–alkyne …

The recent remarkable progress in azide chemistry has realized sequential conjugation
methods with selective 1, 2, 3-triazole formation. On the basis of the diverse reactivities of …

This paper reports on the selective conversion of alkyl azido groups at the carbonyl α-
position to diazo compounds. Through β-elimination of dinitrogen, followed by hydrazone …

Herein we report the first alkynylation of quinolones with terminal alkynes under mild
reaction conditions. The reaction is catalyzed by Cu (I) salts in the presence of a Lewis acid …

Divergent synthesis of triazoles was achieved using newly designed platform molecules
possessing azide, alkyne, and fluorosulfonyl moieties. Consecutive conjugations by the …