AMPK is mitochondrial medicine for neuromuscular disorders
Duchenne muscular dystrophy (DMD), myotonic dystrophy type 1 (DM1), and spinal
muscular atrophy (SMA) are the most prevalent neuromuscular disorders (NMDs) in children …
muscular atrophy (SMA) are the most prevalent neuromuscular disorders (NMDs) in children …
Molecular pathways involved in the control of contractile and metabolic properties of skeletal muscle fibers as potential therapeutic targets for Duchenne muscular …
A Bonato, G Raparelli, M Caruso - Frontiers in Physiology, 2024 - frontiersin.org
Duchenne muscular dystrophy (DMD) is caused by mutations in the gene encoding
dystrophin, a subsarcolemmal protein whose absence results in increased susceptibility of …
dystrophin, a subsarcolemmal protein whose absence results in increased susceptibility of …
Spermidine-eIF5A axis is essential for muscle stem cell activation via translational control
Q Zhang, W Han, R Wu, S Deng, J Meng, Y Yang, L Li… - Cell Discovery, 2024 - nature.com
Adult skeletal muscle stem cells, also known satellite cells (SCs), are quiescent and activate
in response to injury. However, the activation mechanisms of quiescent SCs (QSCs) remain …
in response to injury. However, the activation mechanisms of quiescent SCs (QSCs) remain …
AMPK as a mediator of tissue preservation: time for a shift in dogma?
Ground-breaking discoveries have established 5′-AMP-activated protein kinase (AMPK) as
a central sensor of metabolic stress in cells and tissues. AMPK is activated through cellular …
a central sensor of metabolic stress in cells and tissues. AMPK is activated through cellular …
[HTML][HTML] AMPK regulates the maintenance and remodelling of the neuromuscular junction
Objective The molecular mechanisms underlying the maintenance and adaptability of the
neuromuscular junction (NMJ) remain poorly understood. This study aimed to investigate the …
neuromuscular junction (NMJ) remain poorly understood. This study aimed to investigate the …
LEDT and Idebenone treatment modulate autophagy and improve regenerative capacity in the dystrophic muscle through an AMPK-pathway
HNM Silva, EM Fernandes, VA Pereira, DS Mizobuti… - Plos one, 2024 - journals.plos.org
Purpose Considering the difficulties and challenges in Duchenne muscular dystrophy
(DMD) treatment, such as the adverse effects of glucocorticoids, which are the main medical …
(DMD) treatment, such as the adverse effects of glucocorticoids, which are the main medical …
[HTML][HTML] Comparative Transcriptome Analysis of Bovine, Porcine, and Sheep Muscle Using Interpretable Machine Learning Models
Y Guo, S Li, R Na, L Guo, C Huo, L Zhu… - Animals: an Open …, 2024 - pmc.ncbi.nlm.nih.gov
Simple Summary This study aimed to conduct a comprehensive analysis of the factors
involved in muscle growth and development, along with their associated biological functions …
involved in muscle growth and development, along with their associated biological functions …
[PDF][PDF] Hormesis as a Therapeutic Mechanism in Alzheimer's Disease and Memory Formation
NR Ricciardi - 2024 - scholarship.miami.edu
Hormesis is a phenomenon characterized by the positive adaptions an organism
experiences after exposure to a low-level stressor. Hormesis is a broad term used as a …
experiences after exposure to a low-level stressor. Hormesis is a broad term used as a …
The Role of AMPK in Neuromuscular Health and Disease
S Ng - 2023 - macsphere.mcmaster.ca
The neuromuscular junction (NMJ) exhibits an extraordinary capacity for adaptation and
plasticity throughout an individual's lifespan. This remarkable adaptability assumes a central …
plasticity throughout an individual's lifespan. This remarkable adaptability assumes a central …