Multisystem inflammatory syndrome in children (MIS-C) emerged in April 2020 in
communities with high COVID-19 rates. This new condition is heterogenous but resembles …

We review the characteristics of SARS-CoV-2 infection in a large number of patients with IEI.
Overall, we found that combined immunodeficiencies, immune dysregulation disorders, and …

Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with
APS-1 | Journal of Experimental Medicine | Rockefeller University Press Skip to Main Content …

SARS-CoV-2 infection can cause severe respiratory COVID-19. However, many individuals
present with isolated upper respiratory symptoms, suggesting potential to constrain viral …

IFN-I and IFN-III immunity in the nasal mucosa is poorly characterized during SARS-CoV-2
infection. We analyze the nasal IFN-I/III signature, namely the expression of ISGF-3 …

Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/ml; in plasma
diluted 1: 10) of IFN-α and/or IFN-ω are found in about 10% of patients with critical COVID …

Autosomal inborn errors of type I IFN immunity and autoantibodies against these cytokines
underlie at least 10% of critical COVID-19 pneumonia cases. We report very rare …

Background It is important to predict which patients infected by SARS-CoV-2 are at higher
risk of life-threatening COVID-19. Several studies suggest that neutralizing auto-antibodies …

Autoantibodies against IFN-α and IFN-ω (type I IFNs) were recently reported as causative for
severe COVID-19 in the general population. Autoantibodies against IFN-α and IFN-ω are …

Type‐I interferons (IFNs) mediate antiviral activity and have emerged as important immune
mediators during coronavirus disease 19 (COVID‐19). Several lines of evidence suggest …