R De Smet, K Marchal - Nature Reviews Microbiology, 2010 - nature.com
Network inference, which is the reconstruction of biological networks from high-throughput data, can provide valuable information about the regulation of gene expression in cells …
Figure 1 iML1515 genome-scale reconstruction.(a) The iML1515 model contains 1,515 open reading frames that encode enzymes that catalyze 2,719 reactions involving 1,192 …
Resilience, a system's ability to adjust its activity to retain its basic functionality when errors, failures and environmental changes occur, is a defining property of many complex systems …
Abstract RegulonDB (http://regulondb. ccg. unam. mx) is one of the most useful and important resources on bacterial gene regulation, as it integrates the scattered scientific …
Abstract Background COnstraint-Based Reconstruction and Analysis (COBRA) methods are widely used for genome-scale modeling of metabolic networks in both prokaryotes and …
To the Editor: Somatic recombination and accumulation of mutations in VDJ segments result in vast heterogeneity of T-cell receptor (TCR) and immunoglobulin repertoires1, 2. High …
One of the pressing open problems of computational systems biology is the elucidation of the topology of genetic regulatory networks (GRNs) using high throughput genomic data, in …
Large genetic engineering projects require more cistrons and consequently more strong and reliable transcriptional terminators. We have measured the strengths of a library of …
After hundreds of generations of adaptive evolution at exponential growth, Escherichia coli grows as predicted using flux balance analysis (FBA) on genome‐scale metabolic models …