Current opinions and areas of consensus on the role of the cerebellum in dystonia

VG Shakkottai, A Batla, K Bhatia, WT Dauer, C Dresel… - The Cerebellum, 2017 - Springer
A role for the cerebellum in causing ataxia, a disorder characterized by uncoordinated
movement, is widely accepted. Recent work has suggested that alterations in activity …

The functional neuroanatomy of dystonia

VK Neychev, RE Gross, S Lehéricy, EJ Hess… - Neurobiology of …, 2011 - Elsevier
Dystonia is a neurological disorder characterized by involuntary twisting movements and
postures. There are many different clinical manifestations, and many different causes. The …

Monogenic variants in dystonia: an exome-wide sequencing study

M Zech, R Jech, S Boesch, M Škorvánek… - The Lancet …, 2020 - thelancet.com
Background Dystonia is a clinically and genetically heterogeneous condition that occurs in
isolation (isolated dystonia), in combination with other movement disorders (combined …

Dystonia as a network disorder: what is the role of the cerebellum?

CN Prudente, EJ Hess, HA Jinnah - Neuroscience, 2014 - Elsevier
The dystonias are a group of disorders defined by sustained or intermittent muscle
contractions that result in involuntary posturing or repetitive movements. There are many …

The focal dystonias: current views and challenges for future research

HA Jinnah, A Berardelli, C Comella… - Movement …, 2013 - Wiley Online Library
The most common forms of dystonia are those that develop in adults and affect a relatively
isolated region of the body. Although these adult‐onset focal dystonias are most prevalent …

New roles for the cerebellum in health and disease

SL Reeber, TS Otis, RV Sillitoe - Frontiers in systems neuroscience, 2013 - frontiersin.org
The cerebellum has a well-established role in maintaining motor coordination and studies of
cerebellar learning suggest that it does this by recognizing neural patterns, which it uses to …

Imaging insights into basal ganglia function, Parkinson's disease, and dystonia

AJ Stoessl, S Lehericy, AP Strafella - The Lancet, 2014 - thelancet.com
Recent advances in structural and functional imaging have greatly improved our ability to
assess normal functions of the basal ganglia, diagnose parkinsonian syndromes …

The anatomical basis of dystonia: current view using neuroimaging

S Lehéricy, MAJ Tijssen, M Vidailhet, R Kaji… - Movement …, 2013 - Wiley Online Library
This review will consider the knowledge that neuroimaging studies have provided to the
understanding of the anatomy of dystonia. Major advances have occurred in the use of …

[HTML][HTML] Deep brain stimulation for movement disorders of basal ganglia origin: restoring function or functionality?

T Wichmann, MR DeLong - Neurotherapeutics, 2016 - Elsevier
Deep brain stimulation (DBS) is highly effective for both hypo-and hyperkinetic movement
disorders of basal ganglia origin. The clinical use of DBS is, in part, empiric, based on the …

Striatal cholinergic dysfunction as a unifying theme in the pathophysiology of dystonia

KLE Jaunarajs, P Bonsi, MF Chesselet… - Progress in …, 2015 - Elsevier
Dystonia is a movement disorder of both genetic and non-genetic causes, which typically
results in twisted posturing due to abnormal muscle contraction. Evidence from dystonia …